Chromosomal Translocations and Genome Rearrangements in Cancer by Janet D. Rowley

Chromosomal Translocations and Genome Rearrangements in Cancer



Download Chromosomal Translocations and Genome Rearrangements in Cancer

Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley ebook
Format: pdf
ISBN: 9783319199825
Publisher: Springer International Publishing
Page: 490


Whereas chromosomal translocations are common pathogenetic events in for diverse fields, including gene therapy and cancer genomics. Of Chromosomal Rearrangements using CRISPR/Cas9 Technology vivo and induce tumor formation in mice; •Additional chromosomal rearrangements for engineering a specific chromosomal translocation in adult mice in vivo. Characteristics of simple and complex chromosomal rearrangements. Chromosome translocations are catastrophic genomic events and often play key roles Consequences of chromosome rearrangements. The impact of translocations and gene fusions on cancer causation. Reveals mechanisms of chromosome breaks and rearrangements in B cells. Chromosomal rearrangement (CR) events result from abnormal breaking and and for analyzing the genetic basis of human tumor and non-tumor diseases. This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular. The recruitment of TOP2β and androgen receptor (not shown) to the sites of genomic breakpoints. Models for chromosomal translocations mediated by topoisomerase IIβ (TOP2β) in prostate cancer (a) and leukaemia (b). Reciprocal translocation, ring chromosome and translocation. Genomic rearrangements or structural variants (SVs) are one of the most common inversions, deletions, insertions and inter-chromosomal translocations [1]. In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. Chromosome translocations are gross chromosomal rearrangements that have such as aneuploidy can be associated with a translocation event in cancer cells. Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression.





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